PREMPRO AND PREMARIN BACKGROUND
HORMONE REPLACEMENT THERAPY (HRT)

Under the guidance of the federal government, the National Heart, and Blood Institute (NHLBI) launched a study to determine the long Term Effects of Prempro, a hormone replacement therapy drug. The study, originally planned to last eight years, was abruptly halted after five years when researchers determined the side effects were so severe they could not continue to give patients the drug.

The (NHLBI) study consisted of more than 16,000 women between ages of 50 to 79. On May 31, 2002, the Data and Safety Monitoring Board made the decision to terminate the clinical trial. The Board was alarmed at increases in heart problems and breast cancer among those women who were given Prempro.

According to the NHLBI, Women who were given Prempro were more likely to develop serious problems compared to those in the Placebo group.

• 26% increase in breast cancer
• 41% increase in strokes
• 100% increase in blood clots
• 22% increase in incidents of cardiovascular disease

Additional side effects associated with Prempro include ovarian cancer, lupus and gall bladder cancer. A study released in May 2003 by the AMA also noted increased risk of Disease and other forms of dementia.

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Douglas B. Hanna, Esq. and Robert M. Anderson, Esq. are NJ Supreme Court certified Civil Trial Attorneys and are members of the Million Dollar Advocates Forum.